5-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid → 5-Chloro-2-((5-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid

HRID 1964010Notes

Reaction equation

HRID 1964010 reaction equation
[CH2:1]([NH:3][C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:7]=[CH:8][C:9]=1[CH3:10])[CH3:2].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[CH2:27][CH2:28][CH2:29][C:30]([OH:32])=O)=[C:21]([C:34]([O:36]C)=[O:35])[CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:33])[CH2:27][CH2:28][CH2:29][C:30]([N:3]([CH2:1][CH3:2])[C:4]2[CH:5]=[C:6]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[CH:7]=[CH:8][C:9]=2[CH3:10])=[O:32])=[C:21]([CH:20]=1)[C:34]([OH:36])=[O:35]

Participants

3

Reactant 2

HCID 510401525-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acidHCID 66877450N-ethyl-4'-fluoro-4-methylbiphenyl-3-amine

Product 1

HCID 442512265-Chloro-2-((5-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid

Procedure

Using the same method as in Example 15-(i), N-ethyl-4′-fluoro-4-methylbiphenyl-3-amine was reacted with the 5-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid to give 5-chloro-2-((5-[ethyl(4′-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid.methyl ester (yield: 62%).

Sources & evidence

ORD record
ord-9a223987702443f4b9f4bc1c21d98ec0
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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