HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid → 5-Chloro-2-((5-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid | HCID 51040152 | — |
| Reactant | N-ethyl-4'-fluoro-4-methylbiphenyl-3-amine | HCID 66877450 | — |
| Product | 5-Chloro-2-((5-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid | HCID 44251226 | — |
Reaction Steps
Using the same method as in Example 15-(i), N-ethyl-4′-fluoro-4-methylbiphenyl-3-amine was reacted with the 5-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid to give 5-chloro-2-((5-[ethyl(4′-fluoro-4-methylbiphenyl-3-yl)amino]-5-oxopentanoyl)amino)benzoic acid.methyl ester (yield: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415479B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9a223987702443f4b9f4bc1c21d98ec0 |
| Source note | uspto-grants-2013_04 |