5-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid → 5-Chloro-2-[(5-(ethyl[5-(furan-3-yl)-2-methylphenyl]amino)-5-oxopentanoyl)amino]benzoic acid

HRID 1964018Notes

Reaction equation

HRID 1964018 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([C:10]2[CH:14]=[CH:13][O:12][CH:11]=2)[CH:7]=[CH:6][C:5]=1[CH3:15])[CH3:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:31])[CH2:25][CH2:26][CH2:27][C:28]([OH:30])=O)=[C:19]([C:32]([O:34]C)=[O:33])[CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:31])[CH2:25][CH2:26][CH2:27][C:28]([N:3]([CH2:1][CH3:2])[C:4]2[CH:9]=[C:8]([C:10]3[CH:14]=[CH:13][O:12][CH:11]=3)[CH:7]=[CH:6][C:5]=2[CH3:15])=[O:30])=[C:19]([CH:18]=1)[C:32]([OH:34])=[O:33]

Participants

3

Reactant 2

HCID 510401525-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acidHCID 66877311N-ethyl-5-(furan-3-yl)-2-methylaniline

Product 1

HCID 442513025-Chloro-2-[(5-(ethyl[5-(furan-3-yl)-2-methylphenyl]amino)-5-oxopentanoyl)amino]benzoic acid

Procedure

Using the same method as in Example 15-(i), N-ethyl-5-(furan-3-yl)-2-methylaniline was reacted with the 5-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-5-oxopentanoic acid obtained in Example 31-(i) to give 5-chloro-2-[(5-(ethyl[5-(furan-3-yl)-2-methylphenyl]amino)-5-oxopentanoyl)amino]benzoic acid.methyl ester (yield: 58%).

Sources & evidence

ORD record
ord-0bf303f18936430e9f1e8692aff08e3f
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

Loading…