Hydrochloric Acid → [6-(3-Chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-amine HCl salt

HRID 19647Notes

Reaction equation

[Cl:1][C:2]1[C:3]([N:8]2[CH2:32][CH2:31][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH:16][C:17]4[CH:25]=[C:24]5[C:20]([C:21]([CH3:30])([CH3:29])[CH2:22][N:23]5C(=O)C)=[CH:19][CH:18]=4)[C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl>CCO>[ClH:1].[Cl:1][C:2]1[C:3]([N:8]2[CH2:32][CH2:31][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH:16][C:17]4[CH:25]=[C:24]5[C:20]([C:21]([CH3:29])([CH3:30])[CH2:22][NH:23]5)=[CH:19][CH:18]=4)[C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 55 °C

Procedure

A mixture of 1-{6-[6-(3-chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-3,3-dimethyl-2,3-dihydro-indol-1-yl}-ethanone (30 mg), EtOH (5 mL), and 5N aqueous HCl (1 mL) was stirred at 55° C. for 10 h. The mixture was concentrated in vacue to give the HCl salt as a light yellow solid (35 mg).

Workup

concentrationThe mixture was concentrated in vacue

Sources & evidence

ORD record: ord-321d8418eebc41bf8eb3b31e5413ba9d
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07745451B2

Reaction notes

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