反应详情

A mixture of 5-hydroxy-2-hydroxymethylpyridine (14 g) and MnO2 (100 g) in isopropylalcohol (600 mL) was stirred under N2 for 20 h. The reaction mixture was filtered and filtrate concentrated under vacuum affording a crude product as a solid (12 g). It was suspended in acetone/acetonitrile (25 mL each) and the solid residue was filtered off. It was washed with cold acetone/acetonitrile 1:1 mixture to give pure 5-hydroxypyridine-2-carboxaldehyde (3 g) as a solid.

1. filtrationThe reaction mixture was filtered
2. concentrationfiltrate concentrated under vacuum
3. customaffording a crude product as a solid (12 g)
4. filtrationthe solid residue was filtered off
5. washIt was washed with cold acetone/acetonitrile 1:1 mixture