反应详情

A mixture of 4-methoxyphenylboronic acid (35 g, 0.23 mol), sodium-4-bromobenzene-sulfonate (50 g, 0.19 mol) and Na2CO3 (200 g) were taken in toluene (1000 ml) and water (500 ml). To this was added Pd(PPh3)4 (11 g, 0.011 mol) and the reaction mixture was refluxed for 12 h under N2 atmosphere. The reaction mixture was cooled, filtered off the solid residue, washed with toluene and acidified with 6N HCl. The solid precipitate was filtered and dried to give 4′-methoxy[1,1′-biphenyl]-4-sulfonic acid (45 g, 88%).

1. temperaturethe reaction mixture was refluxed for 12 h under N2 atmosphere
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered off the solid residue
4. washwashed with toluene
5. filtrationThe solid precipitate was filtered
6. customdried