HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4'-Methoxybiphenyl-4-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4'-Methoxy[1,1'-biphenyl]-4-sulfonic acid | HCID 23433401 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4'-Methoxybiphenyl-4-sulfonyl chloride | HCID 2794750 | 95% |
Reaction Steps
To a mixture of 4′-methoxy[1,1′-biphenyl]-4-sulfonic acid (30 g, 0.11 mol) and thionylchloride (90 ml), DMF (1 ml) was added and the reaction mixture was refluxed for 6 h. Excess thionylchloride was distilled off and the crude was purified by column chromatography over silica gel (pet. ether/CHCl3, 1:1) to give 4′-methoxy[1,1′-biphenyl]-4-sulfonyl chloride (30 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f8a0d384ca5d4d08bda8575ab7f16fe2 |
| Source note | uspto-grants-2013_04 |