反应详情

To a mixture of 4′-methoxy[1,1′-biphenyl]-4-sulfonic acid (30 g, 0.11 mol) and thionylchloride (90 ml), DMF (1 ml) was added and the reaction mixture was refluxed for 6 h. Excess thionylchloride was distilled off and the crude was purified by column chromatography over silica gel (pet. ether/CHCl3, 1:1) to give 4′-methoxy[1,1′-biphenyl]-4-sulfonyl chloride (30 g, 95%).

1. additionwas added
2. temperaturethe reaction mixture was refluxed for 6 h
3. distillationExcess thionylchloride was distilled off
4. customthe crude was purified by column chromatography over silica gel (pet. ether/CHCl3, 1:1)