HRID1964827

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75919

2-(2-Aminoethyl)pyridine

C7H10N2

结构：CS(=O)(=O)OCC[C@H](NC(=O)[C@@H]1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccccc1

HCID60036776

未命名化合物

2 次

PRODUCTS

生成物

结构：O=C(NC(CCNCCc1ccccn1)c1ccccc1)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1

HCID60036760

未命名化合物

PROCEDURE

实验过程

Following the general method B as outlined in Example 16, starting from 3-({[3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate (Intermediate 9) and 2-(2-pyridinyl)ethanamine, the title compound was obtained in 97.4% purity by HPLC.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16a128ace73e4efdbafd4de53708bd7b
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08415480B2
来源说明: uspto-grants-2013_04

反应 SMILES

CS(O[CH2:6][CH2:7][C@H:8]([NH:15][C:16]([C@H:18]1[N:22]([S:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:21][CH2:20][S:19]1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=O)=O.[N:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[CH2:44][CH2:45][NH2:46]>>[C:29]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:30]=[CH:31][C:26]([S:23]([N:22]2[CH2:21][CH2:20][S:19][CH:18]2[C:16]([NH:15][CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][NH:46][CH2:45][CH2:44][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][N:38]=2)=[O:17])(=[O:25])=[O:24])=[CH:27][CH:28]=1