HRID1964931

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9221

Indazole

C7H6N2

HCID105034

Isocyanate

CNO-

HCID2769629

1-butoxy-4-isocyanatobenzene

C11H13NO2

HCID10149096

5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine

C13H9FN2

PRODUCTS

生成物

结构：CCCCOc1ccc(NC(=O)Nc2cccc(C(=O)c3c[nH]c4ncc(-c5ccc(F)cc5)cc34)c2)cc1

HCID58086709

未命名化合物

PROCEDURE

实验过程

Additional compounds were prepared following the protocol of Scheme 66, optionally substituting 5-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine 605 with a suitable azaindole in Step 1 and/or optionally substituting 1-butoxy-4-isocyanato-benzene 608 with a suitable isocyanate in Step 3. Azaindoles were purchased or prepared as described in Examples 9 or 17, The following compounds were prepared by this procedure:

WORKUP

后处理

customAdditional compounds were prepared
customprepared
customThe following compounds were prepared by this procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-761aff48efae468ab34ab0585c459084
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08415469B2
来源说明: uspto-grants-2013_04

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[CH:16]=[CH:15][NH:14][C:11]3=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)C=N1.[CH2:26]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N:37]=[C:38]=[O:39])=[CH:33][CH:32]=1)[CH2:27][CH2:28][CH3:29].[N-]=[C:41]=[O:42]>>[CH2:26]([O:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:17][C:25]2[CH:20]=[CH:21][CH:22]=[C:23]([C:41]([C:16]3[C:10]4[C:11](=[N:12][CH:13]=[C:8]([C:5]5[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=5)[CH:9]=4)[NH:14][CH:15]=3)=[O:42])[CH:24]=2)=[O:39])=[CH:33][CH:32]=1)[CH2:27][CH2:28][CH3:29]