HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indazole → 1-(4-Butoxy-phenyl)-3-{3-[5-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indazole | HCID 9221 | — |
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 1-Butoxy-4-isocyanatobenzene | HCID 2769629 | — |
| Reactant | 5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine | HCID 10149096 | — |
| Product | 1-(4-Butoxy-phenyl)-3-{3-[5-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-urea | HCID 58086709 | — |
Reaction Steps
Additional compounds were prepared following the protocol of Scheme 66, optionally substituting 5-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine 605 with a suitable azaindole in Step 1 and/or optionally substituting 1-butoxy-4-isocyanato-benzene 608 with a suitable isocyanate in Step 3. Azaindoles were purchased or prepared as described in Examples 9 or 17, The following compounds were prepared by this procedure:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415469B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-761aff48efae468ab34ab0585c459084 |
| Source note | uspto-grants-2013_04 |