反应详情

温度

0 °C

The Boc-containing compound 34 (2.0 g, 3.0 mmol) was dissolved in DCM (30 mL) and cooled to 0° C. TFA (10 mL) was added and the reaction mixture was slowly warmed to ambient temperature. After 2 h, the reaction mixture was concentrated in vacuo and the crude residue was dissolved in EtOAc and washed successively with saturated aqueous NaHCO3 and brine. The organic extract was dried over anhydrous Na2SO4, filtered, and concentrated to afford 1.75 g of compound 35 as a white solid. Mass spectrum, m/z [573.1] (M+H)+.

1. temperaturethe reaction mixture was slowly warmed to ambient temperature
2. concentrationthe reaction mixture was concentrated in vacuo
3. dissolutionthe crude residue was dissolved in EtOAc
4. washwashed successively with saturated aqueous NaHCO3 and brine
5. extractionThe organic extract
6. dry with materialwas dried over anhydrous Na2SO4
7. filtrationfiltered
8. concentrationconcentrated