HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → HCID 67607604, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 3-Hydroxy-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester | HCID 67607394 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67607604 | HCID 67607604 | — |
Reaction Steps
To a solution of bicyclic alcohol 43 (6.5 g, 17.9 mmol) in DCM (20 mL) at 0° C. was added 4N HCl/1,4-dioxane (20 mL, 80 mmol) and the reaction mixture was slowly warming to ambient temperature. After 90 min, an additional portion of 4N HCl/1,4-dioxane (20 mL) was added. After 3 h, the reaction mixture was diluted with toluene and concentrated in vacuo. The crude 52 (HCl salt) was used in the next step without further purification. Mass spectrum, m/z [262.5] (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415486B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-1a947cc43a1e4660910ef82df76e2308 |
| Source note | uspto-grants-2013_04 |