HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methyl 3,4-diaminobenzoate dihydrochloride | HCID 18174510 | — |
| Solvent | Water | HCID 962 | — |
| Product | methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate | HCID 10352553 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
Methyl 3,4-diaminobenzoate dihydrochloride (20 g, 0.08 mol) was mixed with urea (6.54 g, 0.11 mol). Reaction mixture was heated at ˜150° C. for 7 hours. After cooling powder was suspended in water (400 ml) and pH of the last one was adjusted to 0.45 with hydrochloric acid. Precipitate was filtered and rinsed with water and hydrochloric acid (pH=1.5). Obtained filter cake was dried at ˜100° C. Yield 15.7 g (97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08416376B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b205719d59934f3bbeef4e52c36908ef |
| Source note | uspto-grants-2013_04 |