反应详情

温度

150 °C

Methyl 3,4-diaminobenzoate dihydrochloride (20 g, 0.08 mol) was mixed with urea (6.54 g, 0.11 mol). Reaction mixture was heated at ˜150° C. for 7 hours. After cooling powder was suspended in water (400 ml) and pH of the last one was adjusted to 0.45 with hydrochloric acid. Precipitate was filtered and rinsed with water and hydrochloric acid (pH=1.5). Obtained filter cake was dried at ˜100° C. Yield 15.7 g (97%).

1. customReaction mixture
2. temperatureAfter cooling powder
3. filtrationPrecipitate was filtered
4. washrinsed with water and hydrochloric acid (pH=1.5)
5. customObtained
6. filtrationfilter cake
7. customwas dried at ˜100° C