反应详情

A mixture of cis/trans ethyl 4-hydroxycyclohexane carboxylate (5.0 g, 29 mmol) and hydrazine hydrate (1.4 g, 29 mmol) was heated at reflux for 24 h. Residual water was removed by azeotropic distillation with toluene. The residue was triturated from tert-butyl methyl ether. The precipitate was collected by filtration and dried in vacuo to give the title compound as white solid in 91% yield.

1. temperaturewas heated
2. temperatureat reflux for 24 h
3. customResidual water was removed by azeotropic distillation with toluene
4. customThe residue was triturated from tert-butyl methyl ether
5. filtrationThe precipitate was collected by filtration
6. customdried in vacuo