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HRID1966037

反应详情

EQUATION

反应方程式

HRID 1966037 的结构方程式

REACTANTS

反应物

1
反应SMILES：CC(C)(C)OC(=O)N1CC[C@H](N(c2ccccc2)c2ccc(Cl)c(Cl)c2)C1
HCID66657281

未命名化合物

PRODUCTS

产物

1
反应SMILES：Cl.Cl.Clc1ccc(N(c2ccccc2)[C@H]2CCNC2)cc1Cl
HCID66657263

未命名化合物

收率 272%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CCO.Cl
溶剂HCID21887872

未命名化合物

PROCEDURE

实验过程

3(S)-[(3,4-dichlorophenyl)phenylamino]pyrrolidine-1-carboxylic acid tert-butyl ester (0.13 g) was dissolved in 1 N hydrochloric acid-ethanol and heated under reflux for one hour. The reaction solution was concentrated to dryness to thereby obtain 0.11 g of brown amorphous solid 3(S)-(3,4-dichlorophenyl)phenylpyrrolidin-3-ylamine hydrochloride.

WORKUP

后处理

  1. temperatureheated
  2. temperatureunder reflux for one hour
  3. concentrationThe reaction solution was concentrated to dryness