HCID 66657281, compound → HCID 66657263, compound

HRID 1966037Notes

Reaction equation

HRID 1966037 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([N:13]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C>Cl.C(O)C>[ClH:26].[ClH:26].[Cl:27][C:22]1[CH:21]=[C:20]([N:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH:25]=[CH:24][C:23]=1[Cl:26]

Participants

3

Reactant 1

HCID 66657281HCID 66657281, compound

Product 1

HCID 66657263HCID 66657263, compoundYield 272%

Reagents, catalysts & solvents 1

HCID 21887872Ethanol hydrochlorideSolvent

Procedure

3(S)-[(3,4-dichlorophenyl)phenylamino]pyrrolidine-1-carboxylic acid tert-butyl ester (0.13 g) was dissolved in 1 N hydrochloric acid-ethanol and heated under reflux for one hour. The reaction solution was concentrated to dryness to thereby obtain 0.11 g of brown amorphous solid 3(S)-(3,4-dichlorophenyl)phenylpyrrolidin-3-ylamine hydrochloride.

Workup

  1. temperatureheated
  2. temperatureunder reflux for one hour
  3. concentrationThe reaction solution was concentrated to dryness

Sources & evidence

ORD record
ord-5e07a6b473ae4f55976908bbc4cc3d15
Source dataset
uspto-grants-2013_04
Patent number
US08420623B2

Reaction notes

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