Ammonia → 5-Hexenimidamide hydrochloride

HRID 19661Notes

Reaction equation

HRID 19661 reaction equation
[ClH:1].[C:2](=[NH:10])(OC)[CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7].[NH3:11]>>[ClH:1].[C:2](=[NH:10])([NH2:11])[CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86630239Methyl 5-hexenimidoate hydrochloride

Product 1

HCID 552849605-Hexenimidamide hydrochloride

Procedure

Methyl 5-hexenimidoate hydrochloride (P3, 1.5 g) was dissolved in NH3 (2M in MeOH, 46 mL) and the mixture was heated to reflux for 2 h. Volatiles were evaporated in vacuo to give 1.45 g of the title compound as brown solid, which was used in the subsequent step without further purification.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 h
  3. customVolatiles were evaporated in vacuo

Sources & evidence

ORD record
ord-eed303558d374f6ab84a1de5e6dcf6e0
Source dataset
uspto-grants-2010_06
Patent number
US07745458B2

Reaction notes

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