Piperazine → HCID 18423149, compound

HRID 1966342Notes

Reaction equation

HRID 1966342 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([O:14][CH3:15])[N:11]=[C:10]([O:16][CH3:17])[CH:9]=1>C(#N)C>[CH3:15][O:14][C:12]1[N:11]=[C:10]([O:16][CH3:17])[CH:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[N:13]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 806004-Chloro-2,6-dimethoxypyrimidine

Product 1

HCID 18423149HCID 18423149, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

Workup

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with aqueous sodium bicarbonate solution
  4. customevaporated

Sources & evidence

ORD record
ord-a895a98daf4a46cd8f09955978a65b18
Source dataset
uspto-grants-2013_04
Patent number
US08420653B2

Reaction notes

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