反应详情

N*4*-(3,4-Dichlorobenzyl)-2-methylquinoline-4,8-diamine (60.0 mg, 0.181 mmole) and bis(2-bromoethyl)ether (83.7 mg, 0.361 mmole) in dimethylformamide (1 mL), were stirred at 100° C. for 90 min in a microwave oven. Water was added and the mixture was extracted with dichloromethane. The organic phases were washed with saturated NaCl solution, dried and the solvent was removed. The residue thus obtained was purified using silica gel chromatography, eluting with dichloromethane:water 90:10. Precipitation in ethyl acetate gave a brownish solid (15 mg, 17%).

1. extractionthe mixture was extracted with dichloromethane
2. washThe organic phases were washed with saturated NaCl solution
3. customdried
4. customthe solvent was removed
5. customThe residue thus obtained
6. customwas purified
7. washeluting with dichloromethane:water 90:10
8. customPrecipitation in ethyl acetate