Methanesulfonyl chloride → N-[2-(4-{[(S)-((S)-1-Allylpiperidin-2-yl)-phenylmethyl]-amino}-2-methylquinolin-8-yloxy)ethyl]methanesulfonamide

HRID 1966524Notes

Reaction equation

HRID 1966524 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@H:5]1[C@@H:10]([NH:17][C:18]1[C:27]2[C:22](=[C:23]([O:28][CH2:29][CH2:30][NH2:31])[CH:24]=[CH:25][CH:26]=2)[N:21]=[C:20]([CH3:32])[CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH:2]=[CH2:3].[CH3:33][S:34](Cl)(=[O:36])=[O:35]>>[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@H:5]1[C@@H:10]([NH:17][C:18]1[C:27]2[C:22](=[C:23]([O:28][CH2:29][CH2:30][NH:31][S:34]([CH3:33])(=[O:36])=[O:35])[CH:24]=[CH:25][CH:26]=2)[N:21]=[C:20]([CH3:32])[CH:19]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 59474789[(S)-((S)-1-Allylpiperidin-2-yl)-phenyl methyl]-[8-(2-aminoethoxy)-2-methylquinolin-4-yl]-amine

Product 1

HCID 59474734N-[2-(4-{[(S)-((S)-1-Allylpiperidin-2-yl)-phenylmethyl]-amino}-2-methylquinolin-8-yloxy)ethyl]methanesulfonamide

Procedure

Preparation was made using a similar procedure as described in example 21. Starting materials were [(S)—((S)-1-allylpiperidin-2-yl)-phenylmethyl]-[8-(2-aminoethoxy)-2-methylquinolin-4-yl]-amine (example 34) and methanesulfonyl chloride.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-6d7d3ecbd7a44d4fa9f1140f2afeb976
Source dataset
uspto-grants-2013_04
Patent number
US08420670B2

Reaction notes

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