Benzenemethanamine, 3,4-dichloro- → HCID 59474745, compound

HRID 1966532Notes

Reaction equation

HRID 1966532 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH2:13][CH2:14][CH3:15])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:16])[CH:3]=1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:21][NH2:22]>O.S([O-])([O-])(=O)=O.[Cu+2]>[Cl:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:21][NH:22][C:2]1[C:11]2[C:6](=[C:7]([O:12][CH2:13][CH2:14][CH3:15])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:16])[CH:3]=1

Participants

4

Reactant 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 43668467HCID 43668467, compound

Product 1

HCID 59474745HCID 59474745, compound

Reagents, catalysts & solvents 1

HCID 61499Cupric sulfate monohydrateCatalyst

Procedure

Preparation was made using a similar procedure as described in example 5, method 5.1. Starting materials were 4-chloro-2-methyl-8-propoxyquinoline and 3,4-dichlorobenzylamine. A catalytic effective amount of copper(II)sulphate hydrate was added to the reaction mixture. The product was purified using silica gel chromatography, eluting with dichloromethane:methanol 90:10.

Workup

  1. customPreparation
  2. customThe product was purified
  3. washeluting with dichloromethane:methanol 90:10

Sources & evidence

ORD record
ord-f2eb8e0e29f047f48370c0c6b573690f
Source dataset
uspto-grants-2013_04
Patent number
US08420670B2

Reaction notes

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