Dimethylformamide → 2-(8-Methoxy-2-methylquinolin-4-ylamino)-2-phenylacetamide

HRID 1966539Notes

Reaction equation

HRID 1966539 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1.[NH2:15][CH:16]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:17]([NH2:19])=[O:18].CN(C)C=O>C(#N)C>[CH3:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([CH3:14])[CH:3]=[C:2]2[NH:15][CH:16]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:17]([NH2:19])=[O:18]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 127912-Amino-2-phenylacetamideHCID 8075834-Chloro-8-methoxy-2-methylquinoline

Product 1

HCID 594747442-(8-Methoxy-2-methylquinolin-4-ylamino)-2-phenylacetamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation was made using a similar procedure as described in example 19, method 19.2. Starting materials were 4-chloro-8-methoxy-2-methylquinoline and 2-amino-2-phenyl-acetamide. Acetonitrile was used as solvent instead of dimethylformamide.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-3f9fd8b0a11b4ab791cd10f06a16590e
Source dataset
uspto-grants-2013_04
Patent number
US08420670B2

Reaction notes

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