反应详情

To a solution of Intermediate 8 (6.41 g, 16.5 mmol) in ethanol (50 mL) was added hydrazine monohydrate (12 mL, 247 mmol). The mixture was stirred at room temperature overnight, concentrated, and the residue was triturated with isopropyl alcohol. The resulting solid was filtered and the solvent removed under reduced pressure. The residue was purified by column chromatography with silica gel, eluting with methylene chloride/ethanol/ammonium hydroxide (80:8:1) to give the title compound (2.31 g, 54%) as oil.

1. concentrationconcentrated
2. customthe residue was triturated with isopropyl alcohol
3. filtrationThe resulting solid was filtered
4. customthe solvent removed under reduced pressure
5. customThe residue was purified by column chromatography with silica gel
6. washeluting with methylene chloride/ethanol/ammonium hydroxide (80:8:1)