HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate → Ethyl 4,4-difluoro-4-phenylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate | HCID 67244021 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 4,4-difluoro-4-phenylbutanoate | HCID 67245996 | — |
Reaction Steps
A solution of Intermediate 20 (1 g, 4.42 mmol) in methanol (20 ml) was hydrogenated in the presence of palladium on charcoal (10 mg, 10%) for 3 hours. The mixture was then filtered over Celite and the solvent removed under reduced pressure. The residue (0.91 g) was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420669B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-a44bae32c2254e2f81cc249152d5adcb |
| Source note | uspto-grants-2013_04 |