HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl]-3-methylbenzene → 2-{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl]-3-methylbenzene | HCID 67245676 | — |
| Reactant | 2-[6-(2,2-Difluoro-2-phenylethoxy)hexyl]-1H-isoindole-1,3(2H)-dione | HCID 67245867 | — |
| Product | 2-{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}-1H-isoindole-1,3(2H)-dione | HCID 67246592 | 40% |
Reaction Steps
Obtained from Intermediate 30 (8.77 g, 26.2 mmol) by the procedure described in Intermediate 8. Purification by column chromatography with silica gel and methylene chloride as eluent gave the title compound (4.0 g, 40%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420669B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-398b98d7ab504e038f72cedb9ca343ff |
| Source note | uspto-grants-2013_04 |