2,2-Difluoro-4-phenylbutan-1-ol → 2-(3-Bromophenyl)-2,2-difluoroethanol

HRID 1966642Notes

Reaction equation

HRID 1966642 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([F:15])([F:14])[C:9](OCC)=[O:10])[CH:5]=[CH:6][CH:7]=1.FC(F)(CCC1C=CC=CC=1)CO>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([F:14])([F:15])[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-olHCID 53419381Ethyl 2-(3-bromophenyl)-2,2-difluoroacetate

Product 1

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanol

Procedure

Obtained from Intermediate 48 (21.1 g, 75.6 mmol) by the procedure described in Intermediate 2. The title compound was obtained (17.2 g, 96%) as oil.

Sources & evidence

ORD record
ord-0170261bc2c943ba8017375fec126489
Source dataset
uspto-grants-2013_04
Patent number
US08420669B2

Reaction notes

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