Hydrochloric Acid → HCID 67245149, compound

HRID 1966645Notes

Reaction equation

HRID 1966645 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][C:17]([C:20]1[CH:21]=[C:22]([NH:26][C:27]([NH:29][CH2:30][C:31]([OH:33])=O)=[O:28])[CH:23]=[CH:24][CH:25]=1)([F:19])[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>O>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][C:17]([C:20]1[CH:21]=[C:22]([N:26]2[C:31](=[O:33])[CH2:30][NH:29][C:27]2=[O:28])[CH:23]=[CH:24][CH:25]=1)([F:19])[F:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67244804HCID 67244804, compound

Product 1

HCID 67245149HCID 67245149, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of Intermediate 60 (3.42 g, 7.4 mmol), water (20 mL) and concentrated HCl (5.5 mL) was heated at 140° C. for 12 hours. The reaction was cooled. The crude was extracted with ethyl acetate (50 mL) and washed with saturated solution of sodium bicarbonate (2×20 mL), water (2×20 mL) and brine (1×20mL), dried (Na2SO4) and concentrated. The titled compound was obtained (2.52 g, 76%) as oil.

Workup

  1. temperatureThe reaction was cooled
  2. extractionThe crude was extracted with ethyl acetate (50 mL)
  3. washwashed with saturated solution of sodium bicarbonate (2×20 mL), water (2×20 mL) and brine (1×20mL)
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c1e68ce596c74ffe8c547df47d0870df
Source dataset
uspto-grants-2013_04
Patent number
US08420669B2

Reaction notes

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