3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

HRID 1966658Notes

Reaction equation

HRID 1966658 reaction equation
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:8].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8]

Participants

3

Reactant 2

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 866583073-(4-Phenylbutoxy)propionaldehyde

Product 1

HCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanalYield 60.3%

Procedure

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

Workup

  1. customPurification by column chromatography with silica gel eluting with methylene chloride

Sources & evidence

ORD record
ord-9e98ee0d72ee4f88bf2264d780f5ceeb
Source dataset
uspto-grants-2013_04
Patent number
US08420669B2

Reaction notes

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