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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966658Generated: October 30, 2026

3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

https://huagongshe.com/reaction/1966658

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 67245950—
Reactant3-(4-Phenylbutoxy)propionaldehydeHCID 86658307—
Product3-(2,2-Difluoro-2-phenylethoxy)propanalHCID 8665831360.3%

Reaction Steps

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08420669B2
Source datasetuspto-grants-2013_04
ORD IDord-9e98ee0d72ee4f88bf2264d780f5ceeb
Source noteuspto-grants-2013_04