Hydrochloric Acid → HCID 66732657, compound

HRID 1966828Notes

Reaction equation

HRID 1966828 reaction equation
[ClH:1].[CH:2]1([NH:8][C:9]2[C:14]([C:15]3[CH2:19][C:18]4([CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]4)[O:17][N:16]=3)=[CH:13][N:12]=[C:11]3[N:32]([CH2:35][CH3:36])[N:33]=[CH:34][C:10]=23)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>>[ClH:1].[CH:2]1([NH:8][C:9]2[C:10]3[CH:34]=[N:33][N:32]([CH2:35][CH3:36])[C:11]=3[N:12]=[CH:13][C:14]=2[C:15]2[CH2:19][C:18]3([CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[O:17][N:16]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66732584HCID 66732584, compound

Product 1

HCID 66732657HCID 66732657, compound

Procedure

Ethanolic hydrochloric acid (25 ml) was added to tert-butyl 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate (700 mg, 0.00148 mole) (example 9) The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure. White solid precipitated, which was dried under vacuum.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customWhite solid precipitated
  3. customwhich was dried under vacuum

Sources & evidence

ORD record
ord-cce11b04ebda4480a8800c06150b35c2
Source dataset
uspto-grants-2013_04
Patent number
US08420666B2

Reaction notes

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