HCID 66732627, compound → HCID 66732901, compound

HRID 1966842Notes

Reaction equation

HRID 1966842 reaction equation
C([NH:8][C:9]1[C:10]2[CH:25]=[N:24][N:23]([CH2:26][CH3:27])[C:11]=2[N:12]=[CH:13][C:14]=1[C:15]1[CH2:22][C:18]2([CH2:21][CH2:20][CH2:19]2)[O:17][N:16]=1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[CH2:26]([N:23]1[C:11]2[N:12]=[CH:13][C:14]([C:15]3[CH2:22][C:18]4([CH2:19][CH2:20][CH2:21]4)[O:17][N:16]=3)=[C:9]([NH2:8])[C:10]=2[CH:25]=[N:24]1)[CH3:27]

Participants

4

Reactant 1

HCID 66732627HCID 66732627, compound

Product 1

HCID 66732901HCID 66732901, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Palladium hydroxide/carbon (1 gm) is added to a solution of N-benzyl-1-ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (1 gm, 0.0022 mole) (example 9) in methanol and the reaction mixture is stirred under hydrogen balloon for about 12 hours. It is filtered through a bed of celite and residue is washed with methanol. The combined filtrate is concentrated under reduced pressure to get the title compound.

Workup

  1. filtrationIt is filtered through a bed of celite and residue
  2. washis washed with methanol
  3. concentrationThe combined filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-179141d0052744cebe05a0986b92df5a
Source dataset
uspto-grants-2013_04
Patent number
US08420666B2

Reaction notes

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