反应详情

A solution of 2-{3,5-difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (5.0 g, 22 mmol) in acetone (25 mL) was added dropwise to 4 M aqueous hydrochloric acid (25 mL, 100 mmol) with ice-water cooling, keeping the temperature below 10° C. Then the mixture was stirred at room temperature for six hours. The resulting mixture was extracted with ethyl acetate (2×) and the combined organic phases were washed with saturated aqueous sodium bicarbonate and brine. The organic layer was then dried and concentrated in vacuo to afford the title compound.

1. customthe temperature below 10° C
2. extractionThe resulting mixture was extracted with ethyl acetate (2×)
3. washthe combined organic phases were washed with saturated aqueous sodium bicarbonate and brine
4. customThe organic layer was then dried
5. concentrationconcentrated in vacuo