HCID 58256459, compound → HCID 44608309, compound

HRID 1967164Notes

Reaction equation

HRID 1967164 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][C:26]([N:29](S(C)(=O)=O)[S:30]([CH3:33])(=[O:32])=[O:31])=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]([NH:29][S:30]([CH3:33])(=[O:31])=[O:32])=[CH:27][CH:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 58256459HCID 58256459, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 44608309HCID 44608309, compound

Procedure

5-[2,6-difluoro-4-(1-hydroxy-1-methyl ethyl)phenyl]-2-({4-[(methylsulfonyl)amino]phenyl}amino)thiophene-3-carboxamide was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (85 mg, 0.272 mmol) and N-(4-bromophenyl)-N-(methylsulfonyl)methanesulfonamide (89 mg, 0.272 mmol) as the starting materials.

Sources & evidence

ORD record
ord-49a47bc17a584d9da845ac5436c00fb1
Source dataset
uspto-grants-2013_04
Patent number
US08420695B2

Reaction notes

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