4-(4-Bromo-benzyl)-thiomorpholine 1,1-dioxide → 2-({4-[(1,1-Dioxidothiomorpholin-4-yl)methyl]phenyl}amino)-5-[4-(methyl sulfonyl)phenyl]thiophene-3-carboxamide

HRID 1967166Notes

Reaction equation

HRID 1967166 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:21]1[CH:35]=[CH:34][C:24]([CH2:25][N:26]2[CH2:31][CH2:30][S:29](=[O:33])(=[O:32])[CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[O:33]=[S:29]1(=[O:32])[CH2:30][CH2:31][N:26]([CH2:25][C:24]2[CH:34]=[CH:35][C:21]([NH:1][C:2]3[S:3][C:4]([C:10]4[CH:11]=[CH:12][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:14][CH:15]=4)=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])=[CH:22][CH:23]=2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 523254684-(4-Bromo-benzyl)-thiomorpholine 1,1-dioxideHCID 582564812-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 446083102-({4-[(1,1-Dioxidothiomorpholin-4-yl)methyl]phenyl}amino)-5-[4-(methyl sulfonyl)phenyl]thiophene-3-carboxamide

Procedure

2-({4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}amino)-5-[4-(methyl sulfonyl)phenyl]thiophene-3-carboxamide was prepared according to the general procedure in Example 1 using 2-amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide (149 mg, 0.503 mmol) and 4-(4-bromobenzyl)thiomorpholine 1,1-dioxide (153 mg, 0.503 mmol) as the starting materials.

Sources & evidence

ORD record
ord-2e74f2c5a19940fbb3a3a6991866c90a
Source dataset
uspto-grants-2013_04
Patent number
US08420695B2

Reaction notes

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