HCID 12811505, compound → HCID 44608312, compound

HRID 1967169Notes

Reaction equation

HRID 1967169 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:34]=[CH:33][C:26]([CH2:27][N:28]2[N:32]=[CH:31][CH:30]=[N:29]2)=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:34]=[CH:33][C:26]([CH2:27][N:28]3[N:29]=[CH:30][CH:31]=[N:32]3)=[CH:25][CH:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 12811505HCID 12811505, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 44608312HCID 44608312, compound

Procedure

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(2H-1,2,3-triazole-2-ylmethyl)phenyl]amino}thiophene-3-carboxamide was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.320 mmol) and 2-(4-bromobenzyl)-2H-1,2,3-triazole (76 mg, 0.320 mmol) as the starting materials.

Sources & evidence

ORD record
ord-4df14d8ae1bb42518afa85fda2fcc4c8
Source dataset
uspto-grants-2013_04
Patent number
US08420695B2

Reaction notes

Loading…