HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynylthiophene → 1-Methyl-3-phenyl-5-thiophen-3-ylethynyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynylthiophene | HCID 3548422 | — |
| Reactant | 1-methyl-3-phenyl-1H-pyrazol-5-yl 4-methylbenzene-1-sulfonate | HCID 86646617 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | 1-Methyl-3-phenyl-5-thiophen-3-ylethynyl-1H-pyrazole | HCID 25221949 | — |
Reaction Steps
This product was prepared from toluene-4-sulfonic acid 2-methyl-5-phenyl-2H-pyrazol-3-yl ester and 3-ethynyl-thiophene following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/EtOAc 95:5; yield (60 mg, 45%); 1H NMR δ (CDCl3): 7.78 (d, J=8.10 Hz, 2H), 7.60 (m, 1H), 7.46-7.29 (m, 4H), 7.22 (m, 1H), 6.77 (s, 1H), 4.05 (s, 3H); LCMS m/z: 264.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420812B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-653c92c2772b4cd18d23e50f26611ac8 |
| Source note | uspto-grants-2013_04 |