HRID1967266

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

反应SMILES：CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21

HCID636044

1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)

C39H32OP2

HCID16731995

未命名化合物

反应SMILES：CC1NC(=O)C(C)(C)C1O[Si](C)(C)C(C)(C)C

HCID67105615

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1c(N2C(=O)C(C)(C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]2C)ccc(C#N)c1Cl

HCID59556867

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

反应SMILES：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]

催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

PROCEDURE

实验过程

Using (4RS,5SR)-4-(tert-butyldimethylsilyloxy)-3,3,5-trimethylpyrrolidin-2-one (200 mg), 2-chloro-4-iodo-3-methylbenzonitrile (250 mg), cesium carbonate (380 mg), tris(dibenzylideneacetone)dipalladium(0) (36 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (45 mg), and in the same manner as in Reference Example 3, the title compound was obtained as a pale-yellow oil (yield: 103 mg, yield: 33.7%).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-813732f229ac41a7bb466a83f81265b0
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08420694B2
来源说明: uspto-grants-2013_04

反应SMILES

[Si:1]([O:8][CH:9]1[CH:13]([CH3:14])[NH:12][C:11](=[O:15])[C:10]1([CH3:17])[CH3:16])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Cl:18][C:19]1[C:26]([CH3:27])=[C:25](I)[CH:24]=[CH:23][C:20]=1[C:21]#[N:22].C(=O)([O-])[O-].[Cs+].[Cs+].C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Si:1]([O:8][C@H:9]1[C@H:13]([CH3:14])[N:12]([C:25]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[C:19]([Cl:18])[C:26]=2[CH3:27])[C:11](=[O:15])[C:10]1([CH3:16])[CH3:17])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]