HCID 59556890, compound → HCID 67105608, compound

HRID 1967349Notes

Reaction equation

HRID 1967349 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[CH:14]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:13](=[O:19])[C:12]([CH3:21])([CH3:20])[C:11]2=[O:22])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C([BH-](C(CC)C)C(CC)C)(CC)C.[Li+].C1COCC1>>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[C@H:14]([CH2:15][CH:16]([CH3:17])[CH3:18])[C@H:13]([OH:19])[C:12]([CH3:20])([CH3:21])[C:11]2=[O:22])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 59556890HCID 59556890, compoundHCID 131725857L-SELECTRIDE tetrahydrofuran

Product 1

HCID 67105608HCID 67105608, compound

Procedure

Using 2-chloro-4-(5-isobutyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (620 mg) and lithium tri(sec-butyl)borohydride-THF solution (2.92 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as a colorless solid (yield: 363 mg, 58%).

Sources & evidence

ORD record
ord-bd31596568e342249e2550b90916492a
Source dataset
uspto-grants-2013_04
Patent number
US08420694B2

Reaction notes

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