HCID 59556993, compound → HCID 67105806, compound

HRID 1967352Notes

Reaction equation

HRID 1967352 reaction equation
[F:1][C:2]1[C:9]([CH3:10])=[C:8]([N:11]2[CH:15]([CH3:16])[C:14](=[O:17])[C:13]([CH3:19])([CH3:18])[C:12]2=[O:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C([BH-](C(CC)C)C(CC)C)(CC)C.[Li+].C1COCC1>>[F:1][C:2]1[C:9]([CH3:10])=[C:8]([N:11]2[C@H:15]([CH3:16])[C@H:14]([OH:17])[C:13]([CH3:19])([CH3:18])[C:12]2=[O:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 59556993HCID 59556993, compoundHCID 131725857L-SELECTRIDE tetrahydrofuran

Product 1

HCID 67105806HCID 67105806, compound

Procedure

Using 2-fluoro-3-methyl-4-(3,3,5-trimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (60 mg) and lithium tri(sec-butyl)borohydride-THF solution (0.33 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as colorless crystals (yield: 41.4 mg, 69%).

Sources & evidence

ORD record
ord-838a76ec587144a090ddbb795c27d926
Source dataset
uspto-grants-2013_04
Patent number
US08420694B2

Reaction notes

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