HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethyl-5-oxopyrrolidin-1-yl]-3-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | (4S,5S)-4-hydroxy-4,5-dimethylpyrrolidin-2-one | HCID 55299894 | — |
| Reactant | 4-Bromo-2-fluoro-3-methylbenzonitrile | HCID 59556913 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethyl-5-oxopyrrolidin-1-yl]-3-methylbenzonitrile | HCID 59556949 | — |
Reaction Steps
Using 4-bromo-2-fluoro-3-methylbenzonitrile (484 mg), (4S,5S)-4-hydroxy-4,5-dimethylpyrrolidin-2-one (350 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (200 mg), tris(dibenzylideneacetone)dipalladium(0) (103 mg) and cesium carbonate (1.08 g), and in the same manner as in Example 62, the title compound was obtained as colorless crystals (yield: 376 mg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420694B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-24ffa515e42a44e98c91649b32a534ba |
| Source note | uspto-grants-2013_04 |