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HRID1967393

反应详情

EQUATION

反应方程式

HRID 1967393 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21
HCID636044

1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)

C39H32OP2

结构：C[C@@H]1NC(=O)C[C@]1(C)O
HCID55299894

未命名化合物

结构：Cc1c(Br)ccc(C#N)c1F
HCID59556913

4-Bromo-2-fluoro-3-methylbenzonitrile

C8H5BrFN

PRODUCTS

生成物

1
结构：Cc1c(N2C(=O)C[C@](C)(O)[C@@H]2C)ccc(C#N)c1F
HCID59556949

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

PROCEDURE

实验过程

Using 4-bromo-2-fluoro-3-methylbenzonitrile (484 mg), (4S,5S)-4-hydroxy-4,5-dimethylpyrrolidin-2-one (350 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (200 mg), tris(dibenzylideneacetone)dipalladium(0) (103 mg) and cesium carbonate (1.08 g), and in the same manner as in Example 62, the title compound was obtained as colorless crystals (yield: 376 mg, 63%).