Ammonia → HCID 68528407, compound

HRID 1967417Notes

Reaction equation

HRID 1967417 reaction equation
[CH2:1]([CH:3]([C:6]1[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=1[C:12]([NH2:14])=[O:13])[CH2:4][CH3:5])[CH3:2].N.CN.C1([NH2:21])CC1>>[NH2:21][N:8]1[C:9]([CH3:11])=[CH:10][C:6]([CH:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[C:7]1[C:12]([NH2:14])=[O:13]

Participants

5

Reactant 4

HCID 222AmmoniaHCID 6329Methylamine2×HCID 69828CyclopropylamineHCID 68528438HCID 68528438, compound

Product 1

HCID 68528407HCID 68528407, compound

Procedure

By the same procedure as a reaction of Example 5, using 3-(1-ethylpropyl)-5-methyl-1H-pyrrole-2-carboxamide (which was provided by the same procedure as a reaction of Example 4, using a saturated aqueous solution of ammonia instead of an aqueous solution of 40% methylamine) instead of the compound prepared in Example 4, using cyclopropylamine instead of 40% aqueous solution of methylamine, and using the corresponding aldehydes instead of the compound prepared in Example 7, the title compound (1.988 g) having the following physical data was obtained.

Workup

  1. customBy the same procedure as a reaction of Example 5
  2. customwas provided by the same procedure as a reaction of Example 4

Sources & evidence

ORD record
ord-d4978e0544ff45ab853f1e417155724f
Source dataset
uspto-grants-2013_04
Patent number
US08420810B2

Reaction notes

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