Benzoic acid, 3-(chlorosulfonyl)- → 3-{[3-(Ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

HRID 1967486Notes

Reaction equation

HRID 1967486 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH:14]1[CH2:19][CH2:18][CH2:17][CH:16]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:15]1>>[CH2:23]([O:22][C:20]([CH:16]1[CH2:17][CH2:18][CH2:19][N:14]([S:2]([C:5]2[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=2)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH2:15]1)=[O:21])[CH3:24]

Participants

3

Reactant 2

HCID 77641Benzoic acid, 3-(chlorosulfonyl)-HCID 98969Ethyl nipecotate

Product 1

HCID 37367863-{[3-(Ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

Procedure

The intended compound (7.12 g, 92%) was produced as a colorless solid according to the method of Reference Example 1 but using 3-(chlorosulfonyl)benzoic acid (5.00 g) and ethyl piperidine-3-carboxylate (7.04 mL) as the starting materials.

Sources & evidence

ORD record
ord-314e8d541ae049b495de30e4530a0354
Source dataset
uspto-grants-2013_04
Patent number
US08420823B2

Reaction notes

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