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HRID1967608

反应详情

EQUATION

反应方程式

HRID 1967608 的结构方程式

REACTANTS

反应物

4
结构：Cc1ccc(S(=O)(=O)N(C)N=O)cc1
HCID6628

N-Methyl-N-nitrosotoluene-4-sulphonamide

C8H10N2O3S

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CCOCC.OCCO
HCID21225595

未命名化合物

结构：CC1=C(O)C(=O)N(c2ccc3nc[nH]c3c2)C1c1c(F)cccc1F
HCID57923985

未命名化合物

PRODUCTS

生成物

1
结构：COC1=C(C)C(c2c(F)cccc2F)N(c2ccc3[nH]cnc3c2)C1=O
HCID178488724

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.O
溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

The compound was synthesized starting from KOH (10 eq in water), diazald (5 eq), ethylene glycol/Et2O (3/1 v/v), 1-(1H-benzo[d]imidazol-6-yl)-5-(2,6-difluorophenyl)-3-hydroxy-4-methyl-1H-pyrrol-2(5H)-one (0.189 g, 0.5 mmol, 1 eq) and MeOH/H2O (90/10 v/v); yield: 0.058 g (32.6%); MS m/z: 356.3 [M+H]+; 1H-NMR: (400 MHz, DMSO-D6) δ: 1.65-1.81 (s, 3H), 3.83-3.93 (s, 3H), 6.14 (s, 1H), 6.83-7.78 (m, 6H), 8.15 (s, 1H), 12.07-12.07 (bs, 1H); HPLC (METHOD [A]): rt 11.24 min (99%)

WORKUP

后处理

  1. customThe compound was synthesized
  2. customrt 11.24 min (99%)