Diazald → HCID 178488724, compound

Participants

Reaction Steps

The compound was synthesized starting from KOH (10 eq in water), diazald (5 eq), ethylene glycol/Et2O (3/1 v/v), 1-(1H-benzo[d]imidazol-6-yl)-5-(2,6-difluorophenyl)-3-hydroxy-4-methyl-1H-pyrrol-2(5H)-one (0.189 g, 0.5 mmol, 1 eq) and MeOH/H2O (90/10 v/v); yield: 0.058 g (32.6%); MS m/z: 356.3 [M+H]+; 1H-NMR: (400 MHz, DMSO-D6) δ: 1.65-1.81 (s, 3H), 3.83-3.93 (s, 3H), 6.14 (s, 1H), 6.83-7.78 (m, 6H), 8.15 (s, 1H), 12.07-12.07 (bs, 1H); HPLC (METHOD [A]): rt 11.24 min (99%)

Provenance & Evidence