1,1,1-Trifluoro-2-iodoethane → HCID 178431472, compound

HRID 1967632Notes

Reaction equation

HRID 1967632 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[C:13]([CH3:14])=[C:12]([OH:15])[C:11](=[O:16])[N:10]1[C:17]1[CH:32]=[CH:31][C:20]2[N:21](C(OC(C)(C)C)=O)[CH:22]=[N:23][C:19]=2[CH:18]=1.[F:33][C:34]([F:38])([F:37])[CH2:35]I>>[F:33][C:34]([F:38])([F:37])[CH2:35][O:15][C:12]1[C:11](=[O:16])[N:10]([C:17]2[CH:32]=[CH:31][C:20]3[NH:21][CH:22]=[N:23][C:19]=3[CH:18]=2)[CH:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[C:13]=1[CH3:14]

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 58433050HCID 58433050, compound

Product 1

HCID 178431472HCID 178431472, compound

Procedure

The compound was synthesized starting from tert-butyl 5-(2-(2,3-difluorophenyl)-4-hydroxy-3-methyl-5-oxo-2H-pyrrol-1(5H)-yl)-1H-benzo[d]imidazole-1-carboxylate (0.441 g, 1 mmol), trifluoroiodoethane (0.15 ml, 1.5 mmol) and P1-tBu (1.38 ml, 1.5 mmol) according to the method described above and was further purified by semi-preparative HPLC.

Workup

  1. customThe compound was synthesized
  2. customwas further purified by semi-preparative HPLC

Sources & evidence

ORD record
ord-346f8288e6464497ad23b07a88aaf3cb
Source dataset
uspto-grants-2013_04
Patent number
US08420828B2

Reaction notes

Loading…