HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → 3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide | HCID 1472078 | — |
Reaction Steps
Ethylacetoacetate (10 g) and 4-(trifluoromethyl) aniline (12.38 g) in xylene (250 ml) was refluxed for 48 hours. Reaction mixture was concentrated and purified by column chromatography to give pure (9.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420856B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-2e118407768b4139bb75aace33afdc3b |
| Source note | uspto-grants-2013_04 |