Ethyl Acetoacetate → 3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide

HRID 1967638Notes

Reaction equation

HRID 1967638 reaction equation
C(O[C:4](=[O:9])[CH2:5][C:6]([CH3:8])=[O:7])C.[F:10][C:11]([F:20])([F:19])[C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[O:7]=[C:6]([CH3:8])[CH2:5][C:4]([NH:16][C:15]1[CH:17]=[CH:18][C:12]([C:11]([F:10])([F:19])[F:20])=[CH:13][CH:14]=1)=[O:9]

Participants

4

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 99644-(Trifluoromethyl)aniline

Product 1

HCID 14720783-oxo-N-(4-(trifluoromethyl)phenyl)butanamide

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Ethylacetoacetate (10 g) and 4-(trifluoromethyl) aniline (12.38 g) in xylene (250 ml) was refluxed for 48 hours. Reaction mixture was concentrated and purified by column chromatography to give pure (9.7 g).

Workup

  1. customReaction mixture
  2. concentrationwas concentrated
  3. custompurified by column chromatography
  4. customto give pure (9.7 g)

Sources & evidence

ORD record
ord-2e118407768b4139bb75aace33afdc3b
Source dataset
uspto-grants-2013_04
Patent number
US08420856B2

Reaction notes

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