反应详情

A mixture of 2-bromo-3-oxo-N-[4-(trifluoromethyl)phenyl]butanamide (10 g) [obtained from above step-b] and sodium cyanide (1.69 g) in DMSO (30 ml) was stirred at room temperature overnight. The reaction mixture was diluted with water (100 ml) and acidified with 50% HCl solution. Precipitated solid was filtered and washed with water. The solid was dried to give Teriflunomide (7.12 g).

1. customPrecipitated solid
2. filtrationwas filtered
3. washwashed with water
4. customThe solid was dried